Even though Deadpool will be making the jump to the MCU, Ryan Reynolds will still be playing the title character, and he’ll certainly be making wisecracks about changing universes with his signature fourth-wall-breaking. Then of course there’s Hugh Jackman, playing Wolverine for what will be the tenth and possibly the final time (though the more multiversal characters we see, the better the odds we’ll get a massive fight scene with all of them in Secret Wars). Reynolds hinted that Jackman’s Wolverine might be a bit different in Deadpool 3, saying in an interview:

“And what we pitched him was enough of a divergence from the character that he knows and the character that he’s left behind, that it gives him something completely new to play and something that he’s really excited to do.”

Multiple returning stars from the first two Deadpool films will be returning, including Wade’s roommate and best friend, Blind Al, played once again by the legendary Leslie Uggams. Also returning is Karan Soni as the soft-spoken taxi-driver Dopinder. Morena Baccarin will also be returning as Vanessa, Wade Wilson’s fiancée who was killed off at the beginning of the sequel, only to be rescued through the use of time travel during the end-credits sequence. In the comics, Vanessa is the former X-Force member Copycat who has the power to replicate superhuman powers and abilities. While there haven’t been any hints that Baccarin’s Vanessa will become more like her comic-book counterpart, that may change in the new film. Maybe time travel had some side effects on her. Stefan Kapicic will also be reprising his scene-stealing role as the goody-two-shoes X-Man Colossus. Vanessa wasn’t the only person Wade saved through the use of time travel at the end of the second film, with Rob Delaney returning to reprise his role as Peter, a human man who auditions and is accepted into the X-Force after seeing an ad in the paper. Additionally, it was confirmed that Brianna Hildebrand and Shioli Kutsuna would return as Negasonic Teenage Warhead and Yukio, respectively. Hildebrand’s young hero made for a perfect sidekick to Wade’s antics, and things got even funnier when paired with Kutsuna’s Yukio in the second film.